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At least 406 people killed in Iran

654 wounded according to Human Rights Activists

DUBAI, United Arab Emirates (AP) — Israel unleashed airstrikes across Iran for a third day Sunday and threatened even greater force as some Iranian missiles evaded Israeli air defenses to strike buildings in the heart of the country. Planned talks on Iran’s nuclear program, which could provide an off-ramp, were canceled.

Israel’s strikes have killed at least 406 people in Iran and wounded another 654, according to a human rights group that has long tracked the country, Washington-based Human Rights Activists. Iran’s government has not offered overall casualty figures.

The region braced for a protracted conflict after Israel’s surprise bombardment Friday of Iranian nuclear and military sites killed several top generals and nuclear scientists. Neither side showed any sign of backing down.

Iran said Israel struck two oil refineries, raising the prospect of a broader assault on Iran’s heavily sanctioned energy industry that could affect global markets. The Israeli military, in a social media post, warned Iranians to evacuate arms factories, signaling a further widening of the campaign.

Israel, the sole though undeclared nuclear-armed state in the Middle East, said it launched the attack to prevent Iran from developing a nuclear weapon. The two countries have been adversaries for decades.